The International Conference for High Performance Computing, Networking, Storage, and Analysis
The International Conference for High Performance Computing, Networking, Storage, and Analysis
Workshop:CAFCW21: Computational Approaches for Cancer Workshop 2021
Authors: T.J. Sego (Indiana University)
Abstract: Modeling the interplay of subcellular, intercellular and environmental factors is critical to producing meaningful, predictive simulations of cancer progression in vivo and testing biological hypotheses with virtual tissues. CompuCell3D is an open-source, cross-platform simulation environment that provides multiscale, multicellular biological modeling and simulation capabilities for a broad range of applications. New modeling, simulation and computing capabilities make CompuCell3D more relevant than ever to testing biological hypotheses in a multicellular context while considering processes that span scales from the subcellular to organismal scales. This talk presents new capabilities of CompuCell3D as relevant to modeling cancer onset and progression. The survey of new features includes capabilities like interactive Boolean network modeling, to computing leveraging high-performance computing environments. New features are demonstrated with examples related to proliferation, immune response and tissue recovery. An overview of an advanced application also demonstrates how CompuCell3D readily supports concurrent, collaborative development of complex modeling and simulation projects.
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